Malignancies after mitoxantrone for multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Malignancies after mitoxantrone for multiple sclerosis
OBJECTIVE To assess the therapy-related risk of malignancies in mitoxantrone-treated patients with multiple sclerosis. METHODS This retrospective observational cohort study included all mitoxantrone-treated patients with multiple sclerosis seen at our department between 1994 and 2007. We collected follow-up information on medically confirmed malignancies, life status, and cause of death, as o...
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BACKGROUND There are few treatment options for patients with secondary progressive and worsening relapsing-remitting multiple sclerosis. Mitoxantrone is an antineoplastic drug, recently approved for treatment of multiple sclerosis. Mitoxantrone is, however, associated with dose-related cardiotoxicity, which limits its use. OBJECTIVE To investigate the possible cardiotoxicity of mitoxantrone i...
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BACKGROUND Multiple sclerosis is a leading cause of disability in young adults. Mitoxantrone has recently been shown to be effective in ameliorating multiple sclerosis activity and reducing the relapse rate. This study aimed to assess the efficacy of mitoxantrone on disease activity and decreasing relapse rate in patients with multiple sclerosis in Iran. METHODS This was a clinical trial on p...
متن کاملSuppression of mitoxantrone cardiotoxicity in multiple sclerosis patients by dexrazoxane.
OBJECTIVE To explore the potential of dexrazoxane to suppress subclinical cardiotoxicity in MS patients receiving mitoxantrone. METHODS An open-label study was performed to evaluate possible subclinical cardiotoxicity in multiple sclerosis patients treated quarterly with mitoxantrone (48 mg/m(2) cumulative), with and without concomitant dexrazoxane, using blinded serial radionucleide ventricu...
متن کاملpreliminary evidence-based pharmacotherapy of mitoxantrone for multiple sclerosis in an iranian population
patients and methods this cross-sectional study on 71 patients with ms was carried out between 2010 and 2012, in an iranian population. demographic and pharmacological variables were recorded in d-base. statistical analyses were performed using spss for windows. results the females/males sex ratio within the study population was 3.17: 1. the mean age of females was 32.2 years old (range 20 - 45...
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ژورنال
عنوان ژورنال: Neurology
سال: 2016
ISSN: 0028-3878,1526-632X
DOI: 10.1212/wnl.0000000000002745